Imagine if the U.S. Constitution barred the EPA and Department of Education from existing. All union protections are dead, there are no more federal workplace safety standards, and even child-labor laws are struck down, along with a national minimum wage.
Imagine that the Constitution makes it illegal for the federal government to protect you from big polluters, big banks and even big food and pharma—all are free to rip you off or poison you all they want, and your only remedy is in state courts and legislatures, because the Constitution prevents Congress from doing anything about any of it. The federal government can't even enforce voting or civil rights laws.